How Long Does Fentanyl Withdrawal Last?

The decision to get sober is a brave step, but it can also be intimidating, especially when it involves detoxing from addictive substances like opioids. For people who have developed a physical dependence on fentanyl, going through withdrawal is often one of the toughest parts of the recovery journey.

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What is Fentanyl Withdrawal?

Fentanyl withdrawal is the body’s response to the absence of the drug after a period of regular use. It’s a complex, multi-faceted process that affects individuals physically and emotionally. This condition arises because fentanyl, a powerful opioid, alters the brain’s chemistry and its response to pain and reward, creating a dependency that is challenging to break.


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Fentanyl Withdrawal Symptoms

Fentanyl withdrawal can manifest in a range of symptoms, which may be both physical and emotional. These may include: 

These symptoms occur as the body and brain attempt to readjust to functioning without the substance it has grown accustomed to. The intensity and duration of these symptoms can vary widely based on several factors, including the length and amount of fentanyl use, the individual’s overall health, and their specific physiology. It’s important to note that fentanyl withdrawal, while uncomfortable and challenging, is a crucial step toward recovery. It signifies the body and brain beginning to heal and adjust to a life free from opioid dependence.

Navigating this process alone can be overwhelming. If you or someone you know is struggling with fentanyl withdrawal, reach out to Profound Treatment today to learn more about our fentanyl and opiate detox programs. You don’t have to face this alone.

Fentanyl Withdrawal Timeline

Fentanyl withdrawal typically unfolds in distinct phases, each characterized by varying symptoms and challenges. Understanding the withdrawal timeline can help individuals and caregivers better prepare for and manage symptoms.

8-16 Hours After Last Use

The withdrawal process usually begins within a few hours to a day after the last use of fentanyl. Early symptoms are often mild and may include: 

  • Muscle aches
  • Restlessness anxiety
  • Intense cravings

These symptoms gradually intensify as the body starts to react more acutely to the absence of fentanyl.

1-3 Days After Last Use

Within a few days after cessation, withdrawal symptoms are most intense. Physical symptoms and emotional symptoms are often present and may include: 

  • Heightened anxiety
  • Irritability
  • Depression
  • Nausea
  • Vomiting
  • Diarrhea
  • Sweating
  • Shivering
  • Increased heart rate
  • Increased blood pressure

The severity of these symptoms can vary based on previous drug use patterns and individual health factors.

5-8 Days After Last Use

Following the peak of fentanyl withdrawal, symptoms generally lessen in severity. This phase can last a week or longer, with symptoms gradually fading. During this time, individuals might still experience cravings and emotional fluctuations, typically less intense than during the peak phase. Physical symptoms like gastrointestinal upset and flu-like symptoms also start to subside, allowing the individual to regain strength and stability.

Throughout all these phases, the role of supportive care cannot be overstated. At Profound Treatment, we understand the intricacies of each phase and offer a range of services, including medical supervision, medication to ease symptoms, and psychological support, to help individuals navigate the withdrawal process safely and comfortably. 

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Factors Affecting Withdrawal Duration

The duration and intensity of fentanyl withdrawal symptoms can vary significantly from person to person. Several key factors influence this variability, making each individual’s experience with withdrawal unique.

  • Duration and intensity of fentanyl use: One of the primary factors is the length of time and the amount of fentanyl an individual has used. Longer periods of use or higher doses can lead to more entrenched physical dependence, resulting in more severe withdrawal symptoms that last longer.
  • Method of fentanyl administration: The method by which fentanyl is administered (injected, smoked, snorted, or transdermal patches) can also affect the withdrawal process. Different methods of administration can alter the speed and intensity with which fentanyl affects the body, potentially influencing the withdrawal timeline.
  • Individual physiology and health: Each person’s unique physiology plays a crucial role. Factors such as metabolism, age, weight, overall health, and genetic predispositions can all impact how the body processes and eliminates fentanyl, thus affecting the withdrawal experience.
  • Co-occurring mental health conditions: Individuals with co-occurring mental health issues, such as anxiety, depression, or post-traumatic stress disorder (PTSD), may experience more intense or prolonged withdrawal symptoms. These conditions can complicate the withdrawal process and require additional therapeutic support.
  • Use of other substances: The concurrent use of other substances, including alcohol or other drugs, can complicate and potentially prolong the withdrawal process. These substances can interact with fentanyl withdrawal, exacerbating symptoms or creating additional health challenges.

Quality of support and treatment: Access to professional medical assistance and supportive care significantly impacts withdrawal. Effective treatment programs can alleviate symptoms, provide emotional support, and reduce the duration of withdrawal. Quality programs typically include medical supervision, medication-assisted treatment (MAT), therapy, and counseling, all tailored to the individual’s needs.

How to Cope With Fentanyl Withdrawal

Coping with fentanyl withdrawal can be challenging, but various strategies and support systems can significantly ease the process. Understanding and utilizing these resources is key to a successful and more comfortable withdrawal experience.


  • Detox programs: Medical detoxification is often the first step in the withdrawal process. These programs, provided by facilities like Profound Treatment, offer a safe and controlled environment where individuals can withdraw from fentanyl under the supervision of healthcare professionals. Medical staff monitor vital signs, provide medications to ease withdrawal symptoms, and ensure the individual’s safety throughout the detox process.
  • Medications: Certain medications can be prescribed to alleviate withdrawal symptoms and cravings. Medications like buprenorphine, methadone, and clonidine are often used to reduce the intensity of withdrawal symptoms, help manage pain, and stabilize mood swings. These medications must be administered under medical supervision as part of a comprehensive treatment plan.
  • Therapy and counseling: Psychological support is crucial in addressing the emotional and mental health aspects of addiction. Individual therapy, cognitive-behavioral therapy (CBT), and other counseling methods can help individuals understand the underlying causes of their addiction, develop coping strategies, and build resilience against relapse. At Profound Treatment, we offer a range of therapy options to cater to individual needs.
  • Support groups: Support groups provide a community of individuals who are going through or have gone through similar experiences. These groups offer a platform for sharing stories, challenges, and successes, which can be incredibly empowering and reassuring. Knowing that others have faced similar struggles and have succeeded in overcoming them can be a significant source of motivation and comfort.
  • Holistic approaches: Incorporating holistic approaches such as yoga, meditation, and acupuncture can also be beneficial. These practices can help reduce stress, improve mental clarity, and enhance overall well-being, making the withdrawal process more manageable.
  • Nutrition and hydration: Proper nutrition and staying hydrated are often overlooked but are essential during withdrawal. A balanced diet can help replenish nutrients, while adequate hydration is crucial for helping the body detoxify and manage symptoms like sweating and diarrhea.
  • Family and community support: Family and friends’ support can be invaluable. Their understanding, encouragement, and practical help can make a significant difference in coping with the challenges of withdrawal.
  • Professional guidance: Lastly, seeking guidance from addiction specialists and healthcare providers is essential. They can offer advice, adjust treatment plans as needed, and provide support throughout the withdrawal process.


At Profound Treatment, we integrate these approaches to provide a comprehensive support system for individuals undergoing fentanyl withdrawal. We aim to make the withdrawal process as manageable as possible and set the foundation for a lasting recovery.

Why Choose Profound for Fentanyl Detox?

Profound Treatment offers a unique combination of expert medical care, personalized treatment plans, and comprehensive support in a nurturing environment, making our program an ideal choice for fentanyl detox. Focusing on physical and emotional well-being, we ensure a tailored approach to detox and recovery, supported by our commitment to your lasting sobriety.

Inpatient Fentanyl Rehab

At Profound Treatment, our inpatient fentanyl rehab program provides a secure, immersive environment for comprehensive recovery. In this setting, clients benefit from around-the-clock care and a structured routine, essential for those in the early stages of recovery from fentanyl addiction. Our inpatient program combines individualized therapy, group sessions, and holistic approaches, all aimed at addressing the root causes of addiction while fostering personal growth and healthy coping mechanisms. The safe and supportive environment is ideal for those who need to step away from daily triggers and focus entirely on their recovery.

medically supervised fentanyl detox

Our medically supervised fentanyl detox ensures that clients undergo withdrawal in the safest and most comfortable manner possible. Under the constant supervision of medical professionals, clients receive care that is tailored to their specific needs, including management of withdrawal symptoms and any medical complications. This careful monitoring not only ensures safety but also lays a strong foundation for the next steps in the recovery process, preparing clients both physically and mentally for ongoing treatment.

medication-assisted treatment for opioid use

Medication-Assisted Treatment (MAT) is a crucial component of our approach to treating opioid addiction. At Profound Treatment, MAT is used to reduce cravings and withdrawal symptoms, making the recovery process more manageable. This method involves the use of FDA-approved medications, in combination with counseling and behavioral therapies, to provide a “whole-patient” approach. MAT has been proven to improve patient survival, increase retention in treatment, and decrease illicit opiate use and other criminal activities among people with substance use disorders.

Recover from Fentanyl Addiction with Profound Treatment

Profound Treatment offers a unique combination of expert medical care, personalized treatment plans, and comprehensive support in a nurturing environment, making our program an ideal choice for fentanyl detox. Focusing on physical and emotional well-being, we ensure a tailored approach to detox and recovery, supported by our commitment to your lasting sobriety.

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